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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDK4
All Species:
44.85
Human Site:
S218
Identified Species:
89.7
UniProt:
P11802
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P11802
NP_000066.1
303
33730
S218
K
P
L
F
C
G
N
S
E
A
D
Q
L
G
K
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001116412
303
33725
S218
K
P
L
F
C
G
N
S
E
A
D
Q
L
G
K
Dog
Lupus familis
XP_538252
303
33686
S218
K
P
L
F
C
G
N
S
E
A
D
Q
L
G
K
Cat
Felis silvestris
Mouse
Mus musculus
P30285
303
33732
S218
K
P
L
F
C
G
N
S
E
A
D
Q
L
G
K
Rat
Rattus norvegicus
P35426
303
33780
S218
K
P
L
F
C
G
N
S
E
A
D
Q
L
G
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001007893
326
36832
S223
K
P
L
F
R
G
N
S
D
V
D
Q
L
G
K
Frog
Xenopus laevis
Q91727
319
35666
S218
K
P
L
F
C
G
N
S
E
A
D
Q
L
C
K
Zebra Danio
Brachydanio rerio
NP_001071245
297
33310
S218
K
P
L
F
C
G
D
S
E
A
D
Q
L
G
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_391955
457
50351
S375
E
P
L
F
P
G
T
S
E
G
D
Q
L
D
R
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_999689
373
42086
S224
R
P
L
F
R
G
Q
S
D
K
D
Q
L
H
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P23111
294
33816
S208
K
P
L
F
P
G
D
S
E
I
D
E
L
F
K
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P24100
294
34012
S208
K
P
L
F
P
G
D
S
E
I
D
Q
L
F
K
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
99.6
97
N.A.
94.7
95
N.A.
N.A.
65.3
72
71.9
N.A.
N.A.
35.2
N.A.
48.7
Protein Similarity:
100
N.A.
99.6
97.6
N.A.
97
97.3
N.A.
N.A.
75.7
79.9
80.1
N.A.
N.A.
50.3
N.A.
60.8
P-Site Identity:
100
N.A.
100
100
N.A.
100
100
N.A.
N.A.
80
93.3
93.3
N.A.
N.A.
60
N.A.
60
P-Site Similarity:
100
N.A.
100
100
N.A.
100
100
N.A.
N.A.
86.6
93.3
100
N.A.
N.A.
73.3
N.A.
73.3
Percent
Protein Identity:
N.A.
43.8
N.A.
45.5
N.A.
N.A.
Protein Similarity:
N.A.
62.7
N.A.
64
N.A.
N.A.
P-Site Identity:
N.A.
66.6
N.A.
73.3
N.A.
N.A.
P-Site Similarity:
N.A.
80
N.A.
80
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
59
0
0
0
0
0
% A
% Cys:
0
0
0
0
59
0
0
0
0
0
0
0
0
9
0
% C
% Asp:
0
0
0
0
0
0
25
0
17
0
100
0
0
9
0
% D
% Glu:
9
0
0
0
0
0
0
0
84
0
0
9
0
0
0
% E
% Phe:
0
0
0
100
0
0
0
0
0
0
0
0
0
17
0
% F
% Gly:
0
0
0
0
0
100
0
0
0
9
0
0
0
59
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
17
0
0
0
0
0
% I
% Lys:
84
0
0
0
0
0
0
0
0
9
0
0
0
0
92
% K
% Leu:
0
0
100
0
0
0
0
0
0
0
0
0
100
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
59
0
0
0
0
0
0
0
0
% N
% Pro:
0
100
0
0
25
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
9
0
0
0
0
92
0
0
0
% Q
% Arg:
9
0
0
0
17
0
0
0
0
0
0
0
0
0
9
% R
% Ser:
0
0
0
0
0
0
0
100
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
9
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
9
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _